Breathe Easy Pediatrics Presents: Tidal Volume Episode 5 – Alveolar Epithelium, Surfactant and Surfactant Proteins

Podcast CreditsWriter: Ryan Thomas, MDProducer: Ryan Thomas, MDReviewers: Christina Barreda, MDElizabeth Fiorino, MDReferences:Andreeva AV Regulation of surfactant secretion in alveolar type II cells 2007 AmJPhyLungBanfi C, Agostoni P. Surfactant protein B: From biochemistry to its potential role as diagnostic and prognostic marker in heart failure. Int J Cardiol. 2016 Oct 15;221:456-62Chroneos ZC, et al. Pulmonary surfactant: an immunological perspective. Cell Physiology and Biochemistry 2010; 25: 13-26.Cole FS, Nogee LM, Hamvas A. Defects in surfactant synthesis: clinical implications. Pediatr Clin N Am 2006; 53: 911-927.Guillot-Alveolar epithelial cells Master regulators of lung homeostasis 2013 IntJBiochemCellBioFrerking I, et al. Pulmonary surfactant: functions, abnormalities, and therapeutic options. Intensive Care Med 2001; 27: 1699-1717.Herzog EL Knowns and Unknowns of the Alveolus PROCATS57778Mason RJ. Biology of alveolar type II cells-2006-RespirologyMurray and Nadel's Textbook of Respiratory Medicine 5th ed. Accessed via MDConsult.Nathan N Surfactant protein A: A key player in lung homeostasis IntJBioCellBio 2016Nkadi PO, et al. An overview of pulmonary surfactant in the neonate: genetics, metabolism, and the role of surfactant in health and disease. Mol Genet Metab 2009; 97: 95-101.Whitsett JA, Wert SE, Weaver TE. Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease. Annual Review of Medicine 2010; 61: 105-119.Wert SE, Whitsett JA, Nogee LM. Genetic disorders of surfactant dysfunction. Pediatr Dev Pathol. 2009; 12(4): 253-274.