#6 Allele-specific expression

I talk about allele-specific expression: why it arises and how it can be
reliably detected.




Sections:


The biology of allele-specific expression (2:17)
Detecting allele-specific expression with RNA-seq (7:46)
Mapping and sequencing biases (16:39)
The experiment in yeast (19:47)
Statistical models (21:44)


Links:


A powerful and flexible statistical framework for testing hypotheses of
allele-specific gene expression from RNA-seq data

Supplemenal information


Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data
The talk by John Marioni
The blog post explaining the RSEM model





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