#319: What is Epidermal Necrolysis?

Epidermal necrolysis refers to severe cutaneous reactions that cause extensive necrosis of tissue and detachment of the epidermis. It encompasses three conditions which are on a continuum of severity and how much of the body’s surface area is affected:

Stevens-Johnson syndrome (SJS): Less than 10% of BSA is detached

Toxic epidermal necrolysis (TEN) - More than 30% of BSA is detached

SJS/TEN overlap: Between 10 and 30% of BSA is detached

In this episode you’ll learn: 

Epidermal necrolysis pathophysiology and risk factors

High risk medications that can cause SJS/TEN

Complications of SJS/TEN

Signs and symptoms in the prodromal and acute phase

Important assessment for a patient with SJS/TEN

Key tests utilized to diagnose and evaluate a patient with epidermal necrolysis

Treatments for SJS/TEN, including medications

Vital education components for patients and families

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