Nipam Patel Part 3: Homeotic (Hox) Genes and Evolution of Crustacean Body Plan
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In his third talk, Patel explores the function of additional Hox genes in the development of crustacean body plans. Using CRISPR-Cas9 genome editing, his laboratory has characterized the expression and function of six of the nine Hox genes in Parhyale, and describes the combinatorial role of Ubx, abdA, and AbdB in the development of specialized appendages in this species, and how changes in the regulation of abdA is responsible for several morphological transitions during crustacean evolution.
Nipam Patel Part 3: Homeotic (Hox) Genes and Evolution of Crustacean Body Plan