B vitamins, drosophila and TANGO2-deficiency disorder

This podcast, and the first paper, are dedicated to the memory of Dr. Nassim Shahrzad, an accomplished scientist with a bright future who was taken from her family, friends and colleagues much too soon. May the memory of her warm smile, collegial nature and devotion to her family serve as a source of comfort and inspiration to all those who knew her.

In this podcast we return to TANGO2-deficiency disorder to hear from Dr Michael Sacher, Dr Christina Miyake and Dr Samuel Mackenzie, on how research in a drosophila disease model correlates with insights from natural history studies on the role for B-complex vitamins in TDD.

Vitamin B5, a coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells
Paria Asadi, et al
https://doi.org/10.1002/jimd.12579

B-complex vitamins for patients with TANGO2-deficiency disorder
Sarah E. Sandkuhler, et al
https://doi.org/10.1002/jimd.12585