The single most important blood test to know your risk of cardiovascular disease | ApoB Masterclass

Episode #315. What is ApoB and why should you care? In this latest instalment of our masterclass series, I’ve distilled the essential insights about apolipoprotein B (ApoB) into one informative episode. Join top experts including Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho as they unravel the significance of ApoB as a crucial marker of cardiovascular health. This episode provides a thorough understanding of why ApoB matters and how it impacts your health.
We unpack the essentials of ApoB, covering its role in cholesterol transport and why it's a key marker for heart disease risk. You'll learn how ApoB affects cardiovascular health, from the way it modifies LDL particles to its impact on atherosclerosis and longevity. We discuss the best ways to measure ApoB, its normal levels, and what causes it to rise. The episode also explores the relationship between ApoB and saturated fats, and why it's a more reliable risk marker than LDL cholesterol. By the end, you'll have a clear understanding of why ApoB matters for your heart health and how it can help guide better health choices.

Specifically, we discuss:

Introduction (00:00)

Lipoproteins & Cholesterol: Transport and Recycling (00:43)

Cholesterol's Role in Lipoproteins (26:40)

Is ApoB a More Accurate Marker of Cardiovascular Risk? (31:13)

Endothelial Transcytosis of Lipoproteins (39:42)

LDL Modification and Aggregation (49:17)

Evidence for ApoB's Role in Atherosclerosis (55:49)

ApoB and Genetics (58:29)

ApoB and Longevity (1:02:16)

Mechanisms Behind Elevated ApoB Levels (1:05:14)

Why ApoB is the Best Predictor of Cardiovascular Disease (1:08:52)

ApoB vs LDL-Cholesterol: Understanding the Discordance (1:21:00)

Healthy ApoB Levels for Young Adults (1:31:39)

Causes of Elevated ApoB Levels (1:45:16)

Target ApoB Levels for Cardiovascular Disease Prevention (2:04:31)

The History and Evolution of the Lipid Hypothesis (2:07:27)

Role of ApoB Lipoproteins in Atherosclerosis (2:10:21)

Importance of ApoB as a Cardiovascular Risk Marker and Its Clinical Application (2:18:39)

Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:27:47)

Top Saturated Fat Foods That Increase Cardiovascular Risk (2:33:53)

Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:35:49)

Dietary Changes to Lower ApoB Levels (2:38:59)

Outro (2:45:54)


Read more about the guests featured on this episode or connect with them on their respective pages on The Proof website: Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho.

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Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants