Memorial Day, Klotho, And The Future Of Our Horses - #128 The Horse's Advocate Podcast

I start this podcast by describing Memorial Day in America, then tie this idea into what is happening in the equine veterinary profession. I only dwell on this briefly because there are more upbeat things to discuss, such as the Klotho protein. The Klotho protein was discovered from an experimental failure and found in all animals. This protein, made up of one thousand amino acids, is primarily produced by the kidneys. A portion of it is then released from the cell, acting as a hormone that can influence cells in distant locations, including the brain. Klotho affects platelets, causing them to release PF4, one of many platelet factors. PF4 stimulates the brain's synapses in 4 hours, causing a profound increase in cognitive functions lasting for 19 days or more after administering it to mice and primates. The hope is that giving this protein will reduce or eliminate cognitive decline, dementia, and Alzheimer's disease in humans. An even more exciting result is the reduction of "all-cause mortality" in mice and primates after raising the amounts of Klotho. Could this also be true in horses? The best way to increase Klotho is exercise, which causes a 30% increase. Feeding adequate amounts of high-quality protein may also help increase Klotho. ********** TheHorsesAdvocate.com is a website for learning about horses, horse barns, and farms. Its membership side allows horse owners to attend live meetings to ask questions and gain a deeper understanding of what they have learned on the site. Membership helps support this message and spread it to everyone worldwide working with horses. HorsemanshipDentistry.com is a website that discusses how and why I perform equine dentistry without immobilization or the automatic use of drugs. I only accept new clients in Florida. TheEquinePractice.com/appointment HorsemanshipDentistrySchool.com is a website for those interested in learning how to perform equine dentistry without drugs on 97% of horses. There are eight spots a year for interested students PLUS, there is a separate online course for those wanting to learn how to do this but can never get to South Florida for hands-on training. Show support for The Horse's Advocate by wearing a hat or shirt or drinking from a cup, all with the official logo. Go to this link for our swag (https://the-horses-advocate.creator-spring.com/). Please give a thumbs up or 5-star review and share these everywhere. I know horse owners worldwide listen, and the horses need every one of you in "Helping Horses Thrive In A Human World."