Circular DNA and RNA Biochemistry, Molecular Biology, and Synthetic Modifications

Circular DNA and RNA molecules, distinguished from their linear counterparts by their covalently closed loop structures, have become pivotal in the fields of molecular biology and biotechnology. These molecules, including plasmids, circular RNA (circRNA), and synthetic constructs, exhibit unique stability and regulatory characteristics, making them valuable for various applications. This review delves into the biochemistry and molecular biology of circular DNA and RNA, explores the range of synthetic modifications possible, and discusses their implications for therapeutic and biotechnological applications.

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