法醫保羅有次驗屍時,意外在屍者顱骨內,發現一張寫有電話號碼的紙條,將他拉進一場匪夷所思的解剖遊戲,一場攸關他女兒漢娜性命的生死遊戲!此時正在黑爾戈蘭島度假的漫畫家琳達,因為一場突如其來的暴風雨被困在島上,但她渾然不知,綁架漢娜的殺人魔薩德勒就在這座島上…。當線索屍體接二連三在與世隔絕的黑爾戈蘭島被發現,法醫保羅只得尋求漫畫家琳達的協助。他要求琳達代他執行一連串解剖任務,只有追查出藏在一具具屍體內的線索,保羅被綁架的女兒漢娜才有可能獲救。

Academy Award® winner Renee Zellweger stars in this terrifying, supernatural thriller about a social worker who has been assigned the unusual and disturbing case of Lillith Sullivan…a girl with a strange and mysterious past. When Emily (Renee Zellweger) opens her home in an attempt to help Lillith, it turns into a deadly nightmare she may not survive. Co–starring Bradley Cooper (The Hangover), Case 39 is a heart-stopping chiller with startling surprises that lead to a shocking and sinister ending.